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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasis of cancer cellsby mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively.The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelialcells and hepatocytes.

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 177-180 doi: 10.1007/s11684-009-0021-x

Abstract: To evaluate the mechanism of vascular endothelial growth factor (VEGF) on the prevention of restenosisadenovirus vector containing hVEGF cDNA was constructed and transfected into vascular smooth muscle cellsThen, the VSMC and human umbilical vein endothelial cells (HUVEC) were divided into control group, H

Keywords： vascular endothelial growth factors     restenosis     reactive oxygen species     endothelial cells     vascular smooth    

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Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 284-286 doi: 10.1007/s11684-009-0062-1

Abstract: To evaluate the role of nitric oxide in the biological effects of vascular endothelial growth factor(VEGF) and the possible mechanism of VEGF, the cultured vascular endothelial cells of rabbit aorta wereThe absorbance () value of vascular endothelial cells and the levels of prostaglandin (PGI), endothelincells and that L-NAME could inhibit the effect of VEGF partially.cells by VEGF.

Keywords： vascular endothelial growth factor     nitric oxide     N-nitro-L-arginine methyl ester     vascular endothelialcells    

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Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 185-191 doi: 10.1007/s11684-007-0035-1

Abstract: population derived from human fetal bone marrow (BM), termed here Flk1CD34 postembryonic pluripotent stem cellsinto the epithelium of liver, lung, gut, as well as the hematopoietic and endothelial lineages after, derma, kidney, and fat and then analyzed the characteristics and function of these stem cells.Morphologically, these cells were fibroblast-like and the doubling time was about 30 h.cells and hepatocytes.

Keywords： endothelial     phenomenon     ectodermal     Flk1CD34 postembryonic     irradiated non-obese    

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Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 297-302 doi: 10.1007/s11684-009-0058-x

Abstract: of human arresten gene was constructed and its secretive expression human embryonic kidney (HEK 293) cellsThe recombinant plasmid was subsequently transfected into HEK 293 cells with LipofectAMINETM2000 ReagentRT-PCR revealed that the mRNA of the target gene was transcribed in the transfected HEK 293 cells.(MTT) assay was carried out to assess their effect on the proliferation of human umbilical vein endothelialumbilical vein endothelial cells .

Keywords： angiogenesis inhibitor     arresten     eukaryotic expression     HEK 293 cells     endothelial cells    

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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: this study was to investigate the effects of resistin on insulin signaling in human umbilical vein endothelialcells (HUVECs).Akt and endothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basalcells under insulin stimulated conditions ( < 0.05 control).cells.

Keywords： resistin     endothelium     nitric oxide     endothelial nitric oxide synthase     Akt-binding protein     mouse    

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Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 356-358 doi: 10.1007/s11684-007-0068-5

Abstract: The effect of hyperlipidemia and inflammation on endothelial functions was studied.group, hyperlipidemia rats showed lower levels of NO and ncreases in leukocyte accumulation on the endothelialsurface, also stronger and more extensive endothelial expression of VCAM-1.In fenofibrate-treated group, the expression of VCAM-1 and leukocyte accumulation on the endothelial

Keywords： endothelial     16-week treatment     leukocyte accumulation     mg/kg     NO    

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Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: addition to affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelialWe are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing

Keywords： COVID-19     endothelial dysfunction     inflammation reaction     cytokine storm    

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Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 196-199 doi: 10.1007/s11684-007-0037-z

Abstract: The aim of this paper was to investigate the effects of resistin on human umbilical vein endothelialcells (HUVECs), and to explore its role and mechanism of action in atherosclerosis.

Keywords： endothelial     resistin stimulation     Incubation     pathogenesis     dysfunction    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelialcells.demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelialIn conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 178-181 doi: 10.1007/s11684-008-0033-y

Abstract: To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood
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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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Title Author Date Type Operation

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Journal Article

Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Journal Article

Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Journal Article

Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Journal Article

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Journal Article

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Journal Article

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Journal Article

Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article